When trying to create a new substance, Mixamo Fuse displays the following message:
WARNING: Could not find C:\Users\siamese\AppData\Local\Temp\Mixamo Fuse\NewCustomSubstance_4.png, reverting to default Diffuse image
Figure : Fuse message

After clicking OK the following message appears:
Substance imported successfully!
Figure : Substance imported successfully

The new substance is blank and the substance collection will have this blank added.
Calibrate the touch mat to resolve the issue. To calibrate the touch mat use these instructions:
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Tap the three horizontal bars displayed at the top-right of the touch mat.
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Tap Settings.Figure : Horizontal bars and Settings
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Tap Calibrate, then follow the on-screen instructions to complete the calibration.